Allosteric Coupling in the Bacterial Adhesive Protein FimH
نویسندگان
چکیده
منابع مشابه
Allosteric Coupling in FimH
Background: The bacterial adhesin FimH is allosterically regulated. Results: Mutations designed to control the allosteric state of the protein created low or high affinity variants as predicted. Conclusion: Three regulatory regions are strongly coupled together, while the active site is more weakly coupled to those regions. Significance: Allosteric regulation can be used to develop antiadhesive...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2013
ISSN: 0021-9258
DOI: 10.1074/jbc.m113.461376